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YOUR Telomere LENGTH IMPACT your HEALTH

Support Your Telomere Length by NUTRITION & LIFESTYLE

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Nutritional Plan for Healthy Telomeres

What Are Telomeres?

Telomeres are segments of DNA which protects the end of our chromosomes when cells divide.

Think like the plastic tips of shoelaces that keep the laces together. Telomeres function similarly, preventing chromosomes from fraying or tangling with one another. When that happens, it can cause genetic information to get mixed up, duplicated, destroyed or leading to cell malfunction. As a result, the telomeres become shorter until the cells are unable to divide further and become inactive or die.

This is how we age.

The rate at which telomeres shorten is accelerated by:

  • Inflammation
  • Oxidative Stress
  • Nutritional Deficiencies
  • Genetic Pre-Disposition
  • and other lifestyle habits

As quicker and faster the length of our telomeres shortness happens, the higher the chance of cell aging, cell death, cardiovascular disease, dementia, stroke, and cancers.

How Is Micronutrient Status Linked to Telomere Length?

Micronutrient status, levels of Omega-3 fatty acids and antioxidant capacity has direct implications for telomere length.

The synergistic effect of micronutrients on the various bodily systems creates a complex web of metabolic pathways that can be profoundly affected by a single nutrient deficiency. This makes it especially important to correct specific deficiencies and maintain micronutrient balance.

Recent studies suggest that high levels of: Homocysteine, Blood Sugar, HA1C, Insulin, Cholesterol, CRP as well as low Vitamin D are associated with telomere length

Protect Your Telomeres, Cellular Health & Vitality by Reducing the Rate at Which Telomeres are Shortened

Telomere Length and Cancer

Telomere length shortens with age. Progressive shortening of telomeres leads to senescence, apoptosis, or oncogenic transformation of somatic cells, affecting the health and lifespan of an individual.

Shorter telomeres have been associated with increased incidence of diseases and poor survival.

The rate of telomere shortening can be either increased or decreased by specific nutrition and lifestyle.

Better choice of diet and activities has a greatest potential to reduce the rate of telomere shortening or at least prevent excessive telomere attrition, leading to delayed onset of age-associated diseases and increased lifespan.

Protect Your Telomeres, Cellular Health & Vitality by Reducing the Rate at Which Telomeres are Shorten.

Strong Immune System and Telomeres

The immune system is highly sensitive to shortening of telomeres since its effectiveness depends on immune cells, specifically white blood cells, ability to proliferate during times of immunological stress.

Although cells of the immune system are unique in that they can up-regulate telomerase unlike other somatic cells, when telomeres of lymphocytes reach a critical minimum length, the ability to activate telomerase in lymphocytes is diminished and adaptive immunity becomes compromised.

Less effective immune response means more infections, increases oxidative stress, inflammation and less defenses against cellular stresses

Individuals with shorter white blood cell telomeres have an 8-fold higher mortality rate for infectious diseases.

The expansion of lymphocytes when confronted with an antigen results in major cell proliferation. Each immune response typically results in 15-20 cell divisions. Once these cells eliminate the antigen, they will usually undergo apoptosis although a few will remain which gives a person life-long immunity to various pathogens. Research has shown that the telomeres of these lymphocytes which have undergone major cell division, but still remain as memory cells do, in fact, have shorter telomeres. Since the immune system depends on the ability of lymphocytes to undergo cell division in response to antigens, telomere shortening can severely limit a person’s immunological defenses.

Protect Your Telomeres, Cellular Health & Vitality by Reducing the Rate at Which Telomeres are Shorten.

Does Your WEIGHT Affect Your Telomere?

Overwhelming evidence suggests that obesity accelerates cell turnover. Weight gain is associated with accelerated telomere loss, body mass index (BMI) and hip circumference are inversely associated with telomere length.

Decreasing visceral fat is very important. Although obese adults have shorter telomeres than their normal weight counterparts, this phenomenon is not present in childhood. One should achieve ideal body weight and body composition with low body fat (less than 22% for women and less than 16% for men).

Obesity is also associated with increased inflammation because fat tissue is a major source of inflammatory cytokines. Since body fat reflects both caloric consumption as well as energy expenditure, which are both directly linked to telomere length, maintaining ideal weight is a fundamental and necessary remedy to reduce telomere attrition.

Protect Your Telomeres, Cellular Health & Vitality by Reducing the Rate at Which Telomeres are Shorten.

Pre-Diabetic, Diabetic & Insulin Resistance Affects Your Telomere

Obesity often coincides with metabolic abnormalities, including insulin resistance and glucose dysregulation, both of which are linked to telomere length.

Research demonstrates that a rise in insulin resistance, which is associated with heightened oxidative stress, accelerates telomere attrition. In fact, when a group of patients were studied for over a decade, a strong relationship between insulin resistance and telomere shortening was demonstrated, especially when it coincided with a gain in body mass index.

Similarly, research has demonstrated short telomeres to be independent predictors of certain diabetic complications, such as kidney disease.

Protect Your Telomeres, Cellular Health & Vitality by Reducing the Rate at Which Telomeres are Shorten.

Is Oxidative Stress Affecting Your Telomere?

Oxidative stress shortens telomeres by inducing single stranded damage in telomeric DNA. Unlike other genes, such chromosomal damage is not repaired in telomeric DNA, and consequently telomeres get shorter with every cellular division, acting as a cellular clock.

Overwhelming evidence links oxidative stress with reduced telomere length, and both are associated with increased cellular turnover. Since the etiology of oxidative stress is so complex, measuring the body’s ability to resist oxidative damage is key.

Antioxidant foods and supplements can potentially reduce oxidative stress very effectively, which will ultimately improve oxidative defenses, mitochondrial function, reduce inflammation and slow vascular turnover at the cellular level.

However, targeted foods and supplementation is necessary, as antioxidants work synergistically and must be balanced to work most effectively and avoid inducing a pro-oxidant effect. Increasing antioxidant capacity at the cellular level is critical to maintaining telomere length.

Nutrition, Lifestyle, Sleep, Stress and Exposures to Toxins will Affect The Cell Age and Cell Health

  • Changing your cells environment
  • Slowing down the speed of the telomere’s break down
  • Reduce cells damage and cells aging
  • Provide needed nutrients
  • Reduce Inflammation

REFERENCES:

1 https://www.ncbi.nlm.nih.gov/pubmed/20064545
2 https://www.ncbi.nlm.nih.gov/pubmed/23500604
3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429334
4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251731
5 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742203
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514221
7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310777
8 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425174