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Secretory Immunoglobulin A (sIgA): The first line of immune defence.

The human body has many mucous surfaces, which represent a grand entrance for foreign microorganisms like pathogens, viruses, bacteria, and parasites.

These surfaces are located in your nose, throat, eyes, and gastrointestinal tract. It is not surprising that such a passable and contact area should be protected safely. The first line in this defence belongs to the immune system, which detects new microorganisms and produces the complex protein Secretory Immunoglobulin A (sIgA) as a defensive response to an invasion. 

Above all, the human immune system responses to the antigens included in these intruders. Immune response injects specific antibodies, the main part of which is sIgA. These antibodies cling to antigens and draw them to the mucous surface, thus preventing deeper penetration, further localization, and progressive colonization by not letting bacteria to breed. 

Probably, it would seem that this is a perfect defensive mechanism, and there is no reason to worry about. We have a responsive immune system, and it does everything for us while we are not even aware of the ongoing micro battles inside our body. Hope so, but what if the mechanism misfires? Particularly, our immune defence works smoothly only when the mucosa is healthy and produces a sufficient amount of sIgA levels.

Nevertheless, this healthy mucosa condition is very fragile and could be wilted by such factors as stress, emotional imbalance, inflammation, anger, frustration, poor nutrition, and psychological pressure. At such moments of a general immunity decline, the production of sIgA slows down or even stops, which leads to the accumulation and uncontrolled exposure of harmful pathogens in the contact area.

Particularly for the gastrointestinal tract, when sIgA production is low, the absorption of incoming food together with potentially dangerous pathogens increases, which makes the gut highly susceptible to infection. 

As an illustrative example, people with food allergies and hypersensitivity lack in sIgA that is why they could experience especially negative reactions to contact with the antibodies included in a particular food.

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Secretory Immunoglobulin A deficit

In some people, the low level of sIgA could appear asymptomatic for an extended period of time, but at critical moments of stress, the lack of antibodies included in sIgA can lead to a weakening of immunity. 

As a result, a variety of symptoms can overtake an individual:

 ● food allergy

● chronic diarrhea

● coeliac disease

● asthma

● autoimmune diseases 

● leaky gut

● uncontrolled weight

In case if sIgA portioning is decreased, foreign microorganisms made their way through the intestinal mucosa and began to accumulate on its walls. Without adequate resistance and control, the intestinal walls become weak, and toxins from pathogens or undigested food particles enter the bloodstream to spread throughout the body. As a defensive reaction to these toxins, the body starts producing another type of antibodies, namely immunoglobulin G (IgG) to protect organs and tissues. Consequently, an individual with a leaky gut and high-level of IgG may experience delayed food reactions.

Diagnosis of troubling sIgA and IgG levels

In order to detect the decreased level of sIgA in your body, Chen Ben Asher Wellness Clinic provides a Comprehensive Stool Analysis, which highlights all the deviations from the norm, indicates the presence of active pathogens with their toxins, and detects disturbed intestinal bacterial balance. Also, the Clinic offers the Food Sensitivity Delayed Test that aims at the detection of delayed reaction on a specific food, including 93 markers that are typically eaten in the western diet. 

This food reaction indicates a high-level of IgG that is producing a result of weakened intestinal walls after the damage caused by pathogens. In such a way, a timely diagnosis could save you from a wide range of symptoms and prevent further abnormal levels of sIgA. 

Click HERE to get qualified advice regarding sIgA levels and further functional nutrition assistance. 

Normalizing sIgA levels

Without a single doubt, it is better not to do experiments with your own health and consult a functional nutrition specialist if you what to prevent decreasing of sIgA levels in your body. 

For this purpose, you can examine the following checkpoints that the Chen Ben Asher Wellness Clinic can hand you after an individual consultation on each troubling matter.

● Elimination of allergic reaction on the specific foods

● Selection of comprehensive approach to the gastrointestinal treatment

● Improving and strengthening the immune system

● Functional nutrition vs chronic condition

● Beneficial supplements to reinforce your health

● Evaluation of stressful contributors for further reducing their source

As you can see, our body is using every tool in its arsenal only to protect us from the external threats. The production of sIgA is only one of a few defensive mechanisms in this struggle for our health. And if any of the natural defensive forces slip out, we must react immediately. Want to keep your body healthy, then take care of the sIgA level as it is one of the most important lines in your defence against hostile intruders. Keep it up, do not leave your immune system in front the danger believing that it will handle by itself. 

Just think, maybe it’s time to step up for each other, not only waiting the immunity will always be your shield. Take care always to get back in need; this is the most durable message that you need to grasp about your immunity.


Stress modulates intestinal secretory immunoglobulin A. Accessed from:

Secretory IgA’s complex roles in immunity and mucosal homeostasis in the gut. Accessed from:

The Biology of Intestinal Immunoglobulin A Responses. Accessed from:



Chen is a Functional Nutrition expert consultant,  leading authority on weight management, women’s health and gluten sensitivity. She is a clinician, public speaker, educator and Amazon Best Seller author of “What If Gluten Free Is Not Enough – The Balanced Diet”.

Chen uses Functional Nutrition to help you find answers to the root causes of your illness and address the biochemical imbalances that may trigger your health and weight. She uses cutting edge lab testing and design the nutritional program to your specific needs as an individual. Food, supplements, lifestyle changes will have integrated to bring balance

If you are looking for personalized nutritional support, we highly recommended contacting Mor’s Nutrition & More Wellness Center in Cupertino, California today.



Mor’s Nutrition & More           |             |              408.966.4972

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