A person can have various gastrointestinal problems that might lead to think about having some real problems that are hard to find the cause. However, the modern medicine has stepped forward, and there is numerous information available about leaky gut and how to treat it.

 

What exactly is leaky gut syndrome?

It is a term that also stands for leaky gut.  To easier to understand how leaky gut, it worth looking more closely to what gut is and what it consists. The gut is “permeable to very small molecules to absorb these vital nutrients.”[1] It is one of the basic functions. However, it can also start working out of the place as for sensitive people where it releases out zonulin. This protein can break junctions in the intestinal lining. The junctions there are tight but that doesn’t mean that they are unbreakable – they can malfunction. There are numerous factors for that:

 

  • Toxins
  • Stress
  • Age
  • Infections

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Guts become “leaky” in the sense that bacteria, parasites, fat and other toxins pass through the bloodstream through “a damaged, hyperpermeable, porous, or leaky gut.”2

 

When guts have become leaky, there are toxins, microbes and even undigested food particles and some other parts that can escape from the intestines into the bloodstream. Of course, the immune system attacks the invaders, but it alone cannot solve all the problems raised. The immune system starts creating antibodies against its tissues. This overstimulation leads to chronic inflammation and disease.

A lot of people suffer from chronic pain, but little of them would think that the reason for that could be leaking gut syndrome. In many cases, there painkillers and even prescribed antibiotics are used. But this just creates even stronger “ “superbugs,” antibiotic-resistant pathogens populating the gastrointestinal tracts.”[2] That is only one of the reasons why it is important to diagnose and treat leaky gut syndrome responsibility.

The solution can be traced down even before the invention of penicillin in 1928 and before aspirin in 1897. The solution is much simpler than it might seem as it is made thanks to nature and it has been around since the beginning of mammalian life and has been the first food of life for humans. To strengthen the immune system, one of the ways is to consume bovine colostrum (cow’s milk). It is a biologic nutraceutical.

Interestingly, also, a newborn has a leaky gut. Mother transfers antibody against every pathogen she has encountered in her life to the newborn. It is up to 2 days after the birth, and further the immune system is upgraded with breastfeeding. It also involves colostrum with epithelial and epidermal growth factors.This leads to further understanding about colostrum can heal leaky gut for an infant and also for older people. Douglas A. Wyatt has further tried to support this hypothesis using pigs. He proved that colostrum prevented glut leaking damage caused by excess stomach acids but also healed existing damage.

This leads to further understanding about colostrum can heal leaky gut for an infant and also for older people. Douglas A. Wyatt has further tried to support this hypothesis using pigs. He proved that colostrum prevented glut leaking damage caused by excess stomach acids but also healed existing damage.[3] Pigs also had around 20% increase in the small intestine area leading to a connection to the improvement of the nutritional absorption of nutrition. Also, there was no need for farmers to use antibiotics as the pigs grew faster and healthier with bigger lean mass and less fat. Further research leads to introducing consortium into the research of people. It was done together with Dr. Raymond Playford at the Imperial College School of Medicine in London and his team.

They come to a conclusion that “taking colostrum reduced the acute NSAID-induced increase in small-intestinal permeability.”[4] [5] [6] Further research lead to the use of proline-rich polypeptides (PRPs) (derived from bovine colostrum) to treat HIV-associated diarrhea caused by opportunistic infections. To these infections, antibiotics had no effect. PRPs regulate the cytokine response that can cause inflammation in the body.

Pain medications and antibiotics

It is known that different pain medications tend to cause bleeding and even holes in the stomach and the intestinal lining. There are risks of taking NSAIDs – according to statistics, there is one lethal outcome in 1200 cases.[7] Pain is the most common leaky gut symptom, and thus, there is a relief needed. Most of the physicians prescribe steroids. However, painkillers can be prescribed to treat pain itself that can come from various other reasons. Not all doctors admit that pain medication can lead to leaky gut syndrome. The Even harsher impact is from antibiotics as they can create more problem due to its destructive nature to kill not only the bad bacteria but also a good one. There are also drug-resistant bacteria that can “colonize and exacerbate leaky gut syndrome.”[8]

There are also other triggers that can lead to the health problems as mentioned earlier problems as well as others. Some of them are birth control pills, GMOs, foods full of pesticides, yeast, molds, excessive use of refined sugars, alcohol, caffeine, surgery and others. Damage consequences might also take years to show up. The major ones are autoimmune diseases that includes “allergies, alopecia areata, Alzheimer’s disease, autism, chronic fatigue syndrome, Crohn’s disease, depression, diabetes, fibromyalgia, food allergies and sensitivities, heart disease, HIV/AIDS, irritable bowel syndrome, inflammatory bowel disease, multiple sclerosis, polymyalgia rheumatic, Raynaud’s disease, rheumatoid arthritis, scleroderma, Sjögren’s syndrome, ulcerative colitis, and vasculitis.”[9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] Destruction and toxins create inflammation that becomes chronic. He type of autoimmune disease depends on the place where is a location of the inflammation.

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Leaky gut is a serious health problem that needs appropriate medical treatment. Antibiotics and painkillers, in this case, are enemies. Further researches in medicine treatment and causes of leaky gut are necessary.

References:

[1] 9 Signs You Have A Leaky Gut. Accessed from: http://www.mindbodygreen.com/0-10908/9-signs-you-have-a-leaky-gut.htmlrel=”nofollow”

[2] Leaky Gut Syndrome: A Modern Epidemic with an Ancient Solution? Accessed from: http://www.townsendletter.com/June2014/leaky0614.htmlrel=”nofollow”

[3]  Borissenko M. Malaysia colostrum piglet clinical trial. Unpublished research. October 2004.

[4] Playford RJ et al. Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Gut. 1999;44:653–658.

[5] Playford RJ et al. Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability.Clin Sci (London). 2001 Jun;100(6):627–633.

[6]  Playford RJ et al. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders. Am J Clin Nutr. 2000;72:5–14.

[7] Tramèr MR et al. Quantitative estimation of rare adverse events which follow a biological progression: a new model applied to chronic NSAID use. Pain. 2000 Mar; 85(1–2):169–182.

[8] Leaky Gut Syndrome: A Modern Epidemic with an Ancient Solution? Accessed from: http://www.townsendletter.com/June2014/leaky0614.htmlrel=”nofollow”

[9] Szaniszlo P et al. New insights into a clinical trial for Colostrinin in Alzheimer’s disease. J Nutr Health Aging. 2009;13(3):235–241.

[10]  Liu Z et al. Tight junctions, leaky intestines, and pediatric diseases. Acta Paediatrica.2005;94(4):386–393.

[11] Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neurol Endocrinol Lett. 2008;29(6):902–910.

[12] Katz KD et al. Intestinal permeability in patients with Crohn’s disease and their healthy relatives. Gastroenterology. 1989 Oct;97(4):927–931.

[13]   Maes M et al. The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neurol Endocrinol Lett. 2008 Feb;29(1):117–124.

[14] Vaarala O. The gut immune system and type 1 diabetes. Ann N Y Acad Sci. 2002 Apr;958:39–46.

[15]  Jackson PG et al. Intestinal permeability in patients with eczema and food allergy. Lancet.1981 June 13;1(8233):1285–1286.

[16] Sharpstone D et al. Small intestinal transit, absorption, and permeability in patients with AIDS with and without diarrhea. Gut. 1999 Jul;45(1):70–76.

[17]   Gecse K et al. Leaky gut in patients with diarrhea-predominant irritable bowel syndrome and inactive ulcerative colitis. Digestion. 2012;85(1):40–46.

[18] Smith MD et al. Abnormal bowel permeability in ankylosing spondylitis and rheumatoid arthritis. J Rheumatol. 1985 Apr;12(2):299–305.

[19]  Munkholm P et al. Intestinal permeability in patients with Crohn’s disease and ulcerative colitis and their first-degree relatives. Gut. 1994 Jan;35(1):68–72.