How does Fructose Impact Metabolism – 22311 Stevens Creek Blvd, Cupertino, CA 95014, USA

We already looked at how sugar affects metabolism, but this time we will look closer at what kind of fructose has an impact on metabolism. It is always present in the diet and body, so it has an inevitable influence on the body.

Fructose metabolism vs. glucose metabolism

It is also interesting to look at the difference between fructose and glucose metabolism because they both are simple sugars. But in the structure they are different. The main difference between glucose and fructose metabolism is that glucose as a source of all tissues can be stored in the body only on demand. Fructose metabolism mostly occurs in the liver, but the excess creates then body fat.

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Fructose can also have a use for making glucose. This process’ name is gluconeogenesis. The process for energy-producing is glycolysis.

What are the main sources of fructose?

It is in various fruits and a bit less in vegetables:

  • Cane
  • Beet
  • Corn (e.g., corn syrup)

Especially in the recent years, it is clear that there is a correlation between added sugar that causes obesity and metabolism problems. It is not an easy task to test an effect of a single sugar, and that is why many studies are inconclusive and lead to further discussions[1].

New research about fructose and metabolism

In the research of the year 2012, examines absorption of fructose, glucose, and sucrose. After all, “The capacity for fructose absorption in humans is not completely clear, but early studies suggested that fructose absorption is quite efficient, though it is less efficient than that of glucose or sucrose.”[2] There is also a big possibility of malnutrition if fructose is absorbed as sole carbohydrate. A person can have not only stomachache, malaise, diarrhea, but also decreased food intake.

Then a professional specialist can prescribe different supplements (e.g., Balance Cellular Phytonutrient Protein) to maintain the necessary nutrient level and help to avoid further fructose metabolism disorders. It is also important to understand fructose impact as all the sugar intakes co-effect and thus change metabolic influxes. In addition, when exercising, glucose has more use as the provider of energy to the body. Furthermore, the whole fructose metabolism is different between people with normal weight (conversion rate 36.4%) and obese or diabetic ones (29.5% and 30.2%)[3]. There is also a difference of fructose and glucose reaction between men and women. The same study also shows that conversion rate for men was 37.4% but for women 28.9%.

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Fructose has various impact on metabolism and whole health. It depends on exercise, health, gender, etc.



[1]Fructose metabolism in humans – what isotopic tracer studies tell us. Accessed from: https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-9-89rel=”nofollow”

[2] Riby JE, Fujisawa T, Kretchmer N: Fructose absorption. Am J Clin Nutr. 1993, 58: 748S-753S.

[3] Paquot N, Schneiter P, Jequier E, Gaillard R, Lefebvre PJ, Scheen A, Tappy L: Effects of ingested fructose and infused glucagon on endogenous glucose production in obese NIDDM patients, obese non-diabetic subjects, and healthy subjects. Diabetologia. 1996, 39: 580-586. 10.1007/BF00403305.

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